Product Name :
RNase L Recombinant Rabbit Monoclonal Antibody [JE36-11]
Predicted band size :
84 kDa
Observed band size :
75 kDa
Synonyms:
2 5A dependent ribonuclease antibody 2 5A dependent RNase antibody 2′ 5′ oligoisoadenylate synthetase dependent antibody 2-5A-dependent ribonuclease antibody 2-5A-dependent RNase antibody DKFZp781D08126 antibody Interferon induced 2 5A dependent RNase antibody MGC104972 antibody MGC133329 antibody PRCA 1 antibody 展开
Function :
Ribonuclease L or RNase L (for latent), known sometimes as ribonuclease 4 or 2′-5′ oligoadenylate synthetase-dependent ribonuclease, is an interferon (IFN)-induced ribonuclease which, upon activation, destroys all RNA within the cell (both cellular and viral). RNase L is an enzyme that in humans is encoded by the RNASEL gene. This gene encodes a component of the interferon-regulated 2′-5’oligoadenylate (2′-5’A) system that functions in the antiviral and antiproliferative roles of interferons.37091-73-9 structure RNase L is activated by dimerization, which occurs upon 2′-5’A binding, and results in cleavage of all RNA in the cell.1,1-Diphenylethan-1-amine Price This can lead to activation of MDA5, an RNA helicase involved in the production of interferons.PMID:33742346
Antibody Type:
Recombinant Rabbit monoclonal Antibody
Immunogen :
Recombinant protein within Human RNase L aa 492-741 / 741.
Species reactivity:
Human
Verify application:
WB
Coupling :
unconjugated
Clone number:
JE36-11
RRID:
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
Storage buffer solution:
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 84 kDa
Positive control :
THP-1 cell lysate, THP-1 treated with 20ng/mL IFN-γ for 48 hours cell lysate, 293T cell lysate, HeLa cell lysate.