Product Name :
RGMA Rabbit Polyclonal Antibody
Predicted band size :
Observed band size :
Synonyms:
Repulsive guidance molecule A antibody RGM antibody RGM domain family member A antibody RGMA antibody RGMA_HUMAN antibody
Function :
Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS1-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.
Antibody Type:
Rabbit Polyclonal Antibody
Immunogen :
KLH conjugated synthetic peptide derived from human Repulsive Guidance Molecule A 301-400/1450
Species reactivity:
Human, Mouse, Rat, Pig, Cow
Verify application:
WB, ELISA
Coupling :
unconjugated
Clone number:
RRID:
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.219640-94-5 custom synthesis The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃.5-Cyano-2-Furancarboxylic acid Chemscene When reconstituted in sterile pH 7.PMID:33709392 4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4℃.
Storage buffer solution:
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
28/50 KDa
Positive control :